En este listado encontrarán diferentes notas de aplicación relacionadas con las soluciones que AGILENT propone para llevar a cabo los controles de calidad de los fármacos biológicos y cumplir así con los CQA’s.
Antibody drug conjugates:
- Analysis of antibody drug conjugates using hydrophobic interaction chromatography with the Agilent 1290 Infinity II Bio LC System
- Mass Spectrometric Characterization of Antibody-siRNA Conjugates using the Agilent 6545XT AdvanceBio LC/Q-TOF
Biosimilars and Biobetters:
- A Comparative Study of the Intact Mass, Subunit Mass, and Released Glycans of Two Rituximab Biosimilars Using High-Resolution LC/MS
- LC/MS/MS Peptide Mapping Comparison of Innovator and Biosimilars of Rituximab
- Charge Variant and Aggregation Analysis of Innovator and Biosimilars of Rituximab
Analysis of Intact protein:
- Precise Characterization of Intact Monoclonal Antibodies by the Agilent 6545XT AdvanceBio LC/Q-TOF
- An Integrated Workflow for Intact and Subunits of Monoclonal Antibody Accurate Mass Measurements
Variant analysis:
- How Shallow Can You Go? Refining charge variant analysis of mAbs with the Agilent 1290 Infinity II Bio LC System
- 2D-LC/MS Characterization of Charge Variants Using Ion Exchange and Reversed-Phase Chromatography
Peptide map analysis and PTMs:
- In-depth Peptide Mapping with Iterative MS/MS Acquisition on the Agilent 6545XT AdvanceBio LC/Q‑TOF
- Assessing Multiple Critical Quality Attributes of Monoclonal Antibody and Comparability Assessments
Aggregation:
Host cell protein analysis:
- Host Cell Protein Analysis Using Agilent AssayMAP Bravo and 6545XT AdvanceBio LC/Q-TOF
- Quantification of Host Cell Protein Impurities using the Agilent 6495C Triple Quadrupole LC/MS
Viral vectors:
Si necesita más información, no dude en contactar con nuestro Especialista de producto Jaume Morales, jaume_morales@agilent.com
